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Pharmaceutical impurities Offered
S.No Impurity Name IUPAC NAME CAS No
I: Quetiapine Fumarate Impurities
1 EP Impurity-A 2-[2-(4-Dibenzo [b,f] [1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-ethyl acetate 844639-07-2
2 EP Impurity-B 11-(Piperazin-1-yl)dibenzo [b,f][1,4]thiazepine.HCl 111974-74-4
3 EP Impurity-C 2-(2-(4-(Dibenzo[b,f][1,4] thiazepin-11-yl)piperazin-1-yl)ethoxy)ethyl 2-(4-(dibenzo[b,f][1,4]thiazepin-11-yl) piperazin 1798840-31-9
4 EP Impurity-D 1,4-Bis(dibenzo[b,f][1,4] thiazepin-11-yl)piperazine                              -1-yl)acetate 945668-94-0
5 EP Impurity-E 1,2-bis[2-(4-Dibenzo [b,f] [1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethane 1371638-05-9
6 EP Impurity-F (2-((2-Aminophenyl)thio) phenyl) (4-(2-(2-hydroxy ethoxy)ethyl)piperazin-1-yl) methanone 848814-27-7
7 EP Impurity-G Dibenzo-(1,4)-thiazepine-11(10H)-One 3159-07-7
8 EP Impurity-H 2-[2-(4-Dibenzo[b,f][1,4] thiazepin-11-yl-piperazin-1-yl-1-oxide)ethoxy]ethanol 1076199-40-0
9  EP Impurity-I 2-[4-(Dibenzo[b,f][1,4] thiazepin-11-yl)piperazin-1-1yl]ethanol.HCl 329218-14-6
10 EP Impurity-J 2-[2-(2-{2-[4-(Dibenzo[b,f] [1,4]thiazepin-11-yl)piperazin -1-yl]ethoxy}ethoxy)ethoxy] ethanol 1356906-17-6
11 EP Impurity-K N-(2-((2-(4-(2-(2-Hydroxy ethoxy)ethyl)piperazine-1-carbonyl)phenyl) thio) phenyl)acetamide HCl 1371638-10-6
12 EP Impurity-L 2-(2-(4-(9-Chlorodibenzo[b,f] [1,4]thiazepin-11-yl)piperazin -1-yl)ethoxy) ethanol 1371638-11-7
13 EP Impurity-N 4-[2-[2-(4-Dibenzo [b,f] [1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethyl]-1-[(2-hydroxyethoxyl)ethyl]-piperazine(U/D) 1800291-86-4
14 EP Impurity-O 11-(4-(2-(2-(Trityloxy)ethoxy) ethyl)piperazin-1-yl)dibenzo [b,f][1,4]thiazepine 844639-06-1
15 EP Impurity-P 11-(4-Ethylpiperazin-1-yl) dibenzo[b,f][1,4]thiazepineHCl 1011758-03-4
16 EP Impurity-Q 4-(Dibenzo[b,f][1,4] thiazepin-11-yl)-1,1-bis[2-(2-hydroxy ethoxy) ethyl]piperazin-1-ium          N/A
17 EP Impurity-R (E)-4-Ethoxy-4-oxobut-2-enoic acid 2459-05-4
18 EP Impurity-S 2-[2-[4-(5-Oxidodibenzo [b,f][1,4]thiazepin-11-yl)-1-piperazinyl]ethoxy]ethanol HCl 329216-63-9
19 EP Impurity-T 4-(Dibenzo[b,f][1,4]thiazepin-11-yl)morpholine 5747-46-6
20 EP Impurity-U Dibenzo[b,f][1,4]thiazepin-11-amine(U/D) 5786-26-5
21 EP Impurity-V 2-(2-(4-(Phenanthridin-6-yl)piperazin-1-yl)ethoxy) ethanol      N/A(U/D)
22 EP Impurity-w 11-(2-(2-(4-(Dibenzo[b,f][1,4] thiazepin-11-yl)piperazin-1-yl)ethoxy)ethoxy) dibenzo [b,f][1,4]thiazepine 1800608-95-0
23 HEEP Impurity 1-[2-(2-Hydroxyethoxy) ethyl]piperazine 13349-82-1
II: ES-Omeprazole Impurities
24 EP Impurity-A 5-methoxy-1H-benzo[d]imidazole-2-thiol 37052-78-1
25 EP Impurity-B 2-(((3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-5-methoxy-1H-benzo[d]imidazole 110374-16-8
26 EP Impurity-C 5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl) methyl) thio)-1H-benzo [d]imidazole. 73590-85-9
27 EP Impurity-D 5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl) methyl)sulfonyl)-1H-benzo [d]imidazole 88546-55-8
28 EP Impurity-E 4-methoxy-2-(((5-methoxy-1H-benzo[d]imidazol-2-yl)sulfinyl)methyl)-3,5-dimethylpyridine 1-oxide 176219-04-8
29 EP Impurity F&G Mixture 1,3-Dimethyl-8-methoxy-12-thioxopyrido[1′,2′:3,4]imidazo[1,2-a]benzimidazol-2(12H)-one and  1,3-                                                            Dimethyl-9-methoxy-12-thioxopyrido[1′,2′:3,4]imidazo[1,2-a]benzimidazol-2(12H)-one Mixture 125656-82-8 & 125656-83-9
30 EP Impurity-H 2-(((4-chloro-3,5-dimethyl pyridin-2-yl)methyl)sulfinyl)-5-methoxy-1H-benzo[d] imidazole 863029-89-4
31 EP Impurity-I 4-methoxy-2-(((5-methoxy-1H-benzo[d]imidazol-2-yl)sulfonyl)methyl)-3,5-dimethylpyridine 1-oxide 158812-85-2
32 Chloro Impurity 2-Chloromethyl-3,5-dimethyl-4-methoxypyridine HCl 86604-75-3
33 Es-Omeprazole impurity at 0.25 RRT 1-(5-methoxy-1H-benzo [d] imidazol-2-yl)-3,5-dimethyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid 1227380-90-6
III: Aspirin Impurities
34 4-Hydroxy benzoic acid 99-96-7
35 4-Hydroxy Isopthalic acid 636-46-4
36 2-Hydroxy benzoic acid 69-72-7
37 2-((2-Acetoxybenzoyl)oxy) benzoic acid 530-75-6
38 2-((2-Hydroxybenzoyl)oxy) benzoic acid 552-94-3
39 2-Acetoxybenzoic anhydride 1466-82-6
IV: Dipyridamole Impurities
40 EP-Impurity-A 2,2′-[[4,6,8-Tri(piperidin-1-yl)pyrimido [5,4-d] pyrimidin-2-yl] nitrilo]diethanoL 16982-40-4
41 EP-Impurity-B 2,2′,2″,2”’,2””,2””’-[[8-(Piperidin-1-yl)pyrimido[5,4-d]pyrimidine-2,4,6-triyl] trinitrilo] hexaethanol 16908-47-7
42 EP-Impurity-C 2,2′-[[6-Chloro-4,8-di (pipe ridin-1-yl)pyrimido[5,4-d] pyrimidin-2-yl]nitrilo]diethanol 54093-92-4
43 EP-Impurity-D 2,2′-[[6-(2-Hydroxyethyl) amino-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidin-2-yl]nitrilo]diethanol 1176886-12-6
44 EP-Impurity-E 2,2′,2”,2’’’-[[6,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine-2,4-diyl] dinitrilo]tetraethanol (U/D)       N/A
45 EP-Impurity-F 2,2′,2”,2’’’-[[4-[(2-hydroxy ethyl)amino]-8-(piperidin-1-yl)-pyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo]tetraethanol (U/D) 60286-30-8
46 EP-Impurity-G 6-Dichloro-4,8-di(piperidin-1-yl)-pyrimido[5,4-d]pyrimidine 7139-02-8
V: Metoprolol Impurities
47 EP-impurity-A (2RS)-1-(Ethylamino)-3-[4-(2-methoxyethyl)phenoxy] propan-2-ol 109632-08-8
48 EP-impurity-B 4-(2-Methoxyethyl)phenol 56718-71-9
49 USP-impurity-B (+/-)1-Chloro-2-hydroxy-3-[4-(2-methoxyethyl) phenoxy]-propane 56718-76-4
50 EP-impurity-C 4-[2-Hydroxy-3-(1-methyl ethyl)aminopropoxy]benzaldehyde 29122-74-5
51 EP-impurity-O (±)-N,N-Bis[2-hydroxy-3-[4-(2-methoxyethyl) phenoxy] propyl](1-methylethyl) amine. hydrochloride 154784-36-8
VI: DiValoprex Sodium Impurities
52 Valeric acid 109-52-4
53 2-Methyl Valeric acid 97-61-0
54 2-Ethyl Valeric acid 20225-24-5
55 2-Butyl Valeric acid       N/A
56 2-Isopropyl Valeric acid 62391-99-5
57 Methyl Valproate 22632-59-3
VII: Ondansetron Impurities
58 EP Impurity-A (3RS)-3-[(dimethylamino) methyl]-9-methyl-1,2,3,9-tetra hydro-4Hcarbazol-4-one.HCl 119812-29-2
59 EP Impurity-C 9-methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one 27387-31-1
60 EP Impurity-D 9-methyl-3-methylene-1,2,3,9-tetrahydro- carbazol-4-4H- one 99614-64-9
61 EP Impurity-E 1H-Imidazole 288-32-4
62 EP Impurity-F 2-Methyl-1H-imidazole 693-98-1
63 EP Impurity-G (3RS)-3-[(1H-Imidazol-1-yl)methyl]-9-Methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one      N/A
64 EP Impurity-H (3RS)-3-[(2-Methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one 9614-14-9
VIII: Aripiprazole Impurities
65 EP Impurity-A 7-Hydroxy-3,4-dihydro quinolin-2(1H)-one 22246-18-0
66 EP Impurity-B 1-(2,3-Dichlorophenyl) piperazine hydrochloride 119532-26-2
67 EP Impurity-C 7-[4-[4-(2-Chlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone 203395-81-7
68 EP Impurity-D 7-[4-[4-(3-Chlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone 203395-82-8
69 EP Impurity-E 7-(4-(4-(2,3-dichlorophenyl) piperazin-1-yl)butoxy)-3,4-quinolin-2(1H)-one 129722-25-4
70 EP Impurity-F 4-(2,3-Dichlorophenyl)-1-[4-(2-oxo-1,2,3,4-tetrahydro quinolin-7-yloxy)butyl] piperazine-1-oxide 573691-09-5
71 EP Impurity-G 1,1′-(Ethane-1,1-diyl)bis(2,3-dichloro-4{4-[3,4-dihydro quin olin-2(1H)-one-7-yloxy butyl] piperazin-1-yl}benzene)(U/D) 1797986-18-5 (Under deve lopment)
72 7-(4-Chlorobutoxy)-3,4-dihydroquinolin-2(1H)-one      N/A
73 USP RC-B 7-(4-Hydroxy-butoxy)-3,4-dihydroquinolin-2(1H)-one 889443-20-3
74 7-(4-Bromobutoxy)-3,4-dihydroquinolin-2-one 129722-34-5
75 7,7′-[Butane-1,4,diylbis(oxy) ]bis[3,4-dihydroquinolin-2 (1H) -one 882880-12-8
76 1-(3,4-Dichloro phenyl) piperazine.HCl 76835-17-1
77 7-Hydroxyquinolin-2(1H)-one 70500-72-0
78 Aripiprazole 3,4-Dichloro Analouge
IX: Riluzole Impurities
79 5-(Trifluoromethoxy) benzo(d)Thiazol-2-amine     N/A
80 4-(Trifluoromethoxy ) benzo(d)Thiazol-2-amine      N/A
81 4-Trifluoromethoxyaniline 461-82-5
82 2,6-dibromo-4-(Trifluoromethoxy)aniline 88149-49-9
83 4-bromo-6-(Trifluoromethoxy)-2-benzothiazolamine 144631-82-3
X: Lansoprazole
84 EP Impurity-A 2-[[[3-Methyl-1-oxido-4-(2,2 ,2-trifluoroethoxy)-2-pyridinyl] methyl]sulfinyl]-1H benz imidazole 213476-12-1
85 EP Impurity- B 2-[[[3-Methyl-4-(2,2,2-tri fluo ro ethoxy)-2-pyridinyl] methyl ]sulfonyl]-1H-benz imidazole 131926-99-3
86 EP Impurity- C 2-[[[3-Methyl-4-(2,2,2-tri fluor oethoxy)-2-pyridinyl] methyl] sulfanyl]-1H-benz imidazole 103577-40-8
87 EP Impurity-D 1H-Benzimidazol-2-ol ; 2-Hydroxybenzimidazole 615-16-7
88 EP Impurity-E 2-Mercaptobenzimidazole 583-39-1
89 EP Impurity-F 2-[(RS)-[(4-Chloro-3-methyl pyridin-2-yl)methyl]sulfinyl]-1H-benzimidazole 168167-42-8
90 Sulphone-N-Oxide  2-[[[3-Methyl-1-oxido-4-(2,2, 2 -trifluoroethoxy)-2-pyridinyl] methyl]sulfonyl]-1H-benz imidazole 953787-54-7
91 Sulphide-N-Oxide 2-[[[3-Methyl-1-oxido-4-(2,2 ,2-trifluoroethoxy)-2-pyridinyl] methyl]sulfanyl]-1H-benz imidazole 163119-30-0
92 S-Isomer 2-[(S)-[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl] methyl]sulfinyl]-1H-benz imidazole 138530-95-7
93 Chloro Impurity 2-Chloromethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride 127337-60-4
XI: Rabeprazole Sodium
94 EP Impurity-A 2-[[4-(3-Methoxypropoxy)-3-methyl-pyridin-2-yl]methyl sulfonyl]benzoimidazole 117976-47-3
95 EP Impurity-B 2-[[4-(3-Methoxypropoxy)-3-methyl-pyridin-2-yl]methyl sulfanyl]benzoimidazole 117977-21-6
96 EP Impurity-C 1-(1H-Benzimidazol-2-yl)-3-methyl-4-oxo-1,4-dihydro pyri dine-2-carboxylic acid (U/D) 1163685-30-0
97 EP Impurity-D 2-[[[1-Oxide-4-(3-methoxy propoxy)-3-methyl-2-pyri dinyl]  methyl]sulfinyl]-1H-benzimidazole 924663-38-7
98 EP Impurity-E 2-[[(4-Methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole 924663-38-7
99 EP Impurity-F 2-Mercaptobenzimidazole 583-39-1
100 EP Impurity-G 2-[[(4-Methoxy-3-methyl-2-pyridinyl)methyl]sulfanyl]-1H-benzimidazole 102804-82-0
101 EP Impurity-H 2-[(RS)-[(4-Chloro-3-methylpyridin-2-yl)methyl] sulphinyl]-1H-benzimidazole; 168167-42-8
102 EP Impurity-I 2-[[[1-Oxide-4-(3-methoxy propoxy)-3-methyl-2-pyri dinyl]  methyl]sulfonyl]-1H-benzimidazole 924663-37-6
103 EP Impurity-K 2-Hydroxybenzimidazole 615-16-7
104 (S)-Isomer Sodium (S)-2-[[4-(3-methoxy propoxy)-3-methyl-pyridin-2-yl]methylsulfinyl] benz imidazole 171440-19-0
105 Chloro impurity 2-Chloromethyl-3-methyl-4-(3-methoxypropoxy)pyridine hydrochloride 153259-31-5
106 EP Impurity-H Sulfide 2-[(RS)-[(4-Chloro-3-methylpyridin-2-yl) methyl] sulphinyl]-1H-benzimidazole 103312-62-5
XII: Paliperidone
107 USP Impurity-A 3-Ethyl-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido [1,2-a]pyrimidin-4-one hydrochloride 849727-64-6
108 USP Impurity-B 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride 84163-13-3
109 USP Impurity-C 3-(2-Chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido-(1,2-a)-pyrimidin-4-one 130049-82-0
110 USP Impurity-D 3-{2-[4-(6-Fluoro-1,2-benz isoxazol-3-yl) piperidin-1-yl] ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido [1,2-a]pyrimidin-4-one N-oxide 761460-08-6
111 9-Keto Impurity 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-7,8-dihydro-2-methyl-4H-pyrido[1,2-a]pyrimidine-4,9(6H)-dione 1189516-65-1
XII: Pantoprazole Impurities
112 EP Impurity-A 5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl) methyl ]sulfonyl]-1H-benzimidazole 127780-16-9
113 EP Impurity-B 5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl) methyl ]thio]-1H-benzimidazole 102625-64-9
114 EP Impurity-C 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole 97963-62-7
115 EP Impurity-D&F Mix 5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl) methyl ]sulfinyl]-1-methyl -1H-benz imidazole &  6-(Difluoro methoxy)-2-[[(3,4-dimethoxy-2-pyridinyl) methyl]sulfinyl]-1-methyl -1H-benzimidazole 624742-53-6 & 721924-06-7
116 N-oxide Impurity 5-(Difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl] sulfinyl} benzimidazol-1-ide N-oxide 953787-60-5
117 Sulphone-N-Oxide 5-(Difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl] sulfonyl} benzimidazol-1-ide N-oxide 953787-55-8
118 Chloro impurity 2-(Chloromethyl)-3,4-dimethoxy pyridinium hydrochloride 72830-09-2
XIV: Duloxetine Impurities
119 EP Impurity-A (3R)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine HCl 910138-96-4 (HCl Salt)
120 EP Impurity-B  (1S)-3-(Methylamino)-1-(thiophen-2-yl)propan-1-ol 116539-55-0
121 EP Impurity-C 4-[(1RS)-3-(Methylamino)-1-(thiophen-2-yl)propyl] naphthalen-1-ol.HCl 949096-01-9 (HBr Salt) (U/D)
122 EP Impurity-D Naphthalen-1-ol  90-15-3
123 EP Impurity-E 2-[(1RS)-3-(Methylamino)-1-(thiophen-2-yl)propyl] naphthalen-1-ol 1033719-36-6 (HCl salt) (U/D)
124 EP Impurity-F (3S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-3-yl)propan-1-amine.HCl(U/D) 1104890-90-5 (HCl salt)
125 EP Impurity-G 1-Fluoronaphthalene 321-38-0
126 USP RC -H (S)-4-(Methyl[3-(naphthalen-1-yloxy)-3-(thiophen-2-yl) propyl] amino)-4-oxo buta noic acid ;                                                            (S)-Duloxetine Succinamide 199191-66-7
XV: Sitagliptin Impurities
127 EP Impurity-A (S)-4-Oxo-4-[3-(trifluoro methyl)-5,6-dihydro [1,2,4] triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl) butan-2-amine phosphate; (S)-Sitagliptin Isomer
128 EP Impurity-B (R)-4-Oxo-4-[3-(trifluoro methyl)-5,6-dihydro[1,2,4] triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,5-difluoro phenyl) butan-2-amine phosphate; Sitagliptin 4-Desfluoro Impurity 1345822-87-8.(U/D)
129 EP Impurity-C (R)-4-Oxo-4-[3-(trifluoro methyl)-5,6-dihydro[1,2,4] triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4-difluoro phenyl) butan-2-amine phosphate; Sitagliptin 5-Desfluoro Impurity 1345822-86-7.(U/D)
120 Sitagliptin FP Impurity-E (3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid 936630-57-8
131 Sitagliptin Triazole.HCl 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 762240-92-6
XVI: Lacosamide Impurities
132 N-Methyl Lacosamide 2-acetamido-N-benzyl-3-methoxy-N-methyl propanamide
133 Desacetyl Desmethyl Lacosamide 2-amino-N-benzyl-3-hydroxypropanamide 175481-39-7
134 N-Desacetyl Lacosamide HCl 2-amino-N-benzyl-3-methoxypropanamide hydrochloride 196601-69-1
135 N-acetyl O-methyl L-serine methyl ester:- methyl 2-acetamido-3-methoxypropanoate
XVII: Furosemide Impurities
136 Furosemide Impurity-A 2-Chloro-4-[(furan-2-yl methyl) amino]-5-sulfamoylbenzoic acid 4818-59-1
1347 Furosemide Impurity-B 2,4-Dichloro-5-sulfamoylbenzoic Acid 2736-23-4
138 Furosemide Impurity-C 2-Amino-4-chloro-5-sulfamoylbenzoic acid 3086-91-7
139 Furosemide Impurity-D 2,4-Bis[(Furan-2-ylmethyl) amino]-5-sulfamoylbenzoic acid 5046-19-5
140 Furosemiiide Impurity-E 2,4-Dichlorobenzoic acid 50-84-0
141 Furosemide Impurity-F 4-Chloro-5-sulfamoyl-2-[[(( 2RS)-tetrahydrofuran-2-yl) methyl]amino]benzoic acid 4793-38-8
XVIII: ITRACONAZOLE Impurities
142 EP Impurity-A 4-[4-[4-(4-Methoxyphenyl) piperazin-1-yl]phenyl]-2-[(1 RS)-1-methylpropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one 252964-68-4
143 EP Impurity-B 4-[4-[4-[4-[[cis-2-(2,4-Di chl orophenyl)-2-(4H-1,2,4-tria zol-4-ylmethyl)-1,3-dioxolan -4-yl]methoxy]phenyl] pipera zin-1-yl]phenyl]-2-[(1RS)-1-methylpropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one 854372-77-3
144 EP Impurity-C 4-[4-[4-[4-[[cis-2-(2,4-Dichlo rophenyl)-2-(1H-1,2,4-triazol -1-ylmethyl)-1,3-dioxolan-4-yl]methoxyphenyl]piperazin-1-yl]phenyl]-2-propyl-2,4-dihydro-3H-1,2,4-triazol-3-one 74855-91-7
145 EP Impurity-D 4-[4-[4-[4-[[cis-2-(2,4-Dichlo rophenyl)-2-(1H-1,2,4-triazol -1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-(1-methyleth yl)-2,4-dihydro-3H-1,2,4-triazol-3-one 89848-49-7
146 EP Impurity-E 4-[4-[4-[4-[[trans-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(1RS)-1-methylpropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one 252964-65-1
147 EP Impurity-F 2-Butyl-4-[4-[4-[4-[[cis-2-(2, 4-dichlorophenyl)-2-(1H-1, 2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy] phe nyl]piperazin-1-yl]phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one 89848-51-1
XIX: RANOLAZINE Impurities
148 USP Related

Compound-A

 1-(2,3-Epoxypropoxy)-2-methoxybenzene 2210-74-4
149 USP Related

Compound-B

 N-(2,6-Dimethylphenyl)-4-(2 -hydroxy-3-phenoxypropyl)-1-piperazineacetamide 755711-09-2
150 USP Related

Compound-C

 N-(2,6-Dimethylphenyl)-1-piperazineacetamide 5294-61-1
151 USP Related

Compound-D

 N,N’-bis(2,6-Dimethyl phe nyl)-1,4-piperazine di acetamide 380204-72-8
XX: Ziprasidone Impurities
152 (ziprasidone compound B 6-chloro-5-(2-chloro-1-hydroxyethyl)indolin-2-one
153 ziprasidone compound C 6-chloroindolin-2-one
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